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In the 2025 RAND survey, about half of patients taking a GLP-1 drug said they experienced nausea and one-third experienced diarrhea

Beyond that, behavioral tests showed that TNF-deficient mice are significantly less sensitive to the bitter compound quinine while their responses to sweet, umami, salty, and sour components remained comparable to those of wild-type mice [118]

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One endocrinologist made the case that common side effects such as nausea and sometimes vomiting could even potentially lead those with type 1 taking the drugs to reduce or stop taking their insulin